Consumption of dietary methionine sulfoxide by intestinal pathogens as a virulence strategy

Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide

PLoS Pathogens, 2017;13(6):e1006428

Vanhove AS, Hang S, Vijayakumar V, Wong CN, Asara JM, Watnick PI.

Using the fly as a model, Audrey Vanhove and Saiyu Hang have discovered a novel virulence mechanism of intestinal pathogens in which consumption of dietary methionine sulfoxide by V. cholerae liberates host methionine sulfoxide reductase to repair oxidized host intestinal proteins required for virulence.

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