Here Liao and colleagues describe an antigen presentation platform based on fusion of antigens to the Vibrio cholerae biofilm matrix protein RbmA with delivery in the form of a whole cell, live-attenuated vaccine. We show that fusion of the B subunit of cholera toxin (CTB) to RbmA and presentation via sublingual delivery of whole cells results in a mucosal immune response to both the V. cholerae O-antigen and CTB.
Paula Watnick's Lab 
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